1988 - Reports of unusual, severe reactions with selective serotonin reuptake inhibitor antidepressant drugs (SSRIs) emerged soon after the first SSRI, Prozac, was introduced in 1988. One of my own patients, a woman with a mild depressive disorder and no history of major psychiatric symptoms, became psychotic after just three days on Prozac. Another woman, a highly successful attorney, developed such severe panic attacks that she couldn't work. Such cases were reported so frequently that ... COP,soldier,criminal...forum.prisonplanet.com/index.php?topic=26915.40
1987 - Prozac was launched in 1987, but it is merely the latest in a 40-year history of developments in antidepressants; it has a lower incidence of side-effects than earlier drugs, though it may also be less effective. Prozac has been skilfully marketed as a 'selective serotonin reuptake inhibitor' (SSRI), though the explanation of the effects of psychoactive drugs in terms of their effects on neurotransmitters has tended to follow their more or less serendipitous discovery and pragmatic ... From Body politicswww.spiked-online.com/Articles/00000006D919.htm
In 1988, the first member of a new drug family arrived on the United States pharmaceutical market with rock star pizzazz and excitement. Fluoxetine, trademarked as Prozac®, was featured on the cover of Newsweek as a breakthrough drug and discussed with passion on radio and television, often by grateful users and sometimes by those concerned over its widespread use for a growing number of conditions. Today, Prozac remains the most widely prescribed antidepressant medicine in history ... From: serotonin, and sadness: the biology of antidep...www.fasebj.org/cgi/content/full/21/13/3404-a
1997 May 26, 1997 - Henry Allen's May 7 Style article "A Capsule History of Psychiatry" is clever but off-base. Although there are those mental health clients who receive relief from marvelous medications such as Prozac and other antidepressants, it is my experience that most depressed persons use ...
From `A Capsule History of Psychiatry' ($$) - Related web pagespqasb.pqarchiver.com/washingtonpost/access/11870325.html?dids=11870325:11870325&FMT=CITE& FMTS=CITE:FT&type=current&date=May+26%2C+1997...History+of...
2000 May 23, 2000 - Article: Antidepressant Alleviates Hot Flashes. Magazine article from: Women's Health Weekly; December 28, 2000 ; 700+ words ......alleviates hot flashes in about 60% of breast cancer survivors...medication for breast cancer, tamoxifen...to cause hot flashes. Hot flashes...history of ...
From Antidepressants Found to Ease Hot Flashes |... ($$) - Related web pageswww.highbeam.com/doc/1P2-528267.html?refid=gnews_209
2001 Aug 4, 2001 - "The history of psychopharmacology is interesting because of how doctors become caught up in the marketing strategies of pharmaceutical companies. Just as soon as the SSRIs go off patent, there will be another generation of antidepressants that will be patented. ...
From Prozac's Reign Ends But Legacy Endures; Drug Has... ($$) - Related web pagespqasb.pqarchiver.com/washingtonpost/access/77013160.html?dids=77013160:77013160&FMT=ABS& FMTS=ABS:FT&type=current&date=Aug+04%2C+2001...
2004 Mar 1, 2004 - There was no difference in tumor estrogen receptor status based upon whether a woman had used antidepressants: 25% of women with a history of antidepressant use had estrogen receptor-negative tumors, as did 23% of patients who'd never used antidepressants.
From Antidepressant use has no effect on breast ca... - Related web pageswww.accessmylibrary.com/premium/0286/0286-916436.html
2005 Nov 21, 2005 - There was outright nonchalance about Michael's mental health and history of antidepressant use, some completely ignored the issue, ... However, since he was on several other antidepressants, and some of those are major antidepressants, we can conclude he has a history of depression as ...
From Dropping The Ball By Karen Ward, RN - Related web pageswww.northcountrygazette.org/articles/112105DroppingTheBall.html
2006 Dec 13, 2006 - “It's like a religious war,” said Edward Shorter, a medical historian at the University of Toronto and author of the definitive “History of ... An analysis by FDA scientists of data from drug trials, released last week, found that adults under 25 who took antidepressants were more than ...
From Panel to Debate Antidepressant Warnings - Related web pageswww.nytimes.com/2006/12/13/us/13suicide.html?pagewanted=print
2007 Jan 22, 2007 - Most women who stop using the drug are under age 40, over 75 or they have a history of antidepressant use, researchers said. About one in five women ended use of the drug within a year, the scientists found after examining prescription records in Ireland. The standard regime for the ...
From Breast Cancer Drug Stopped Early by One in Five... - Related web pageswww.bloomberg.com/apps/news?pid=20601082&sid=aq.FC6MV3gsQ&refer=canada
2008 Jul 20, 2008 - SIDE EFFECTS: A BESTSELLING DRUG ON TRIAL. Alison Bass. 240 pages, Algonquin Books, $24.95. It's hard not to cheer for the little guy in "Side Effects," the true story of underdogs who stand up to powerful drug companies and their questionable ethics. It's also a story that needs to be ...
From History of Prozac fight gives hope to underdogs ($$) - Related web pagespqasb.pqarchiver.com/timesdispatch/access/1515325551.html?dids=1515325551:1515325551&FMT=ABS &FMTS=ABS:FT&type=current&date=Jul+20%2C...History...
Multiple authors
Related link: http://www.google.com/archivesearch?hl=en&q=what+is+the+history+of+antidepressants&um=1&ie=UTF-8&scoring=t&ei=d2LqSrfpB9WUtge0oqU7&sa=X&oi=timeline_result&ct=title&resnum=11&ved=0CC0Q5wIwCg
FDA
The U.S Food and Drug Administration (FDA) proposed that makers of all antidepressant medications update the black box warning on their antidepressants labels to include warnings of increased risks of suicidal thinking and behavior, known as suicidality, in young adults ages 18 to 24 during initial treatment.
The following website lists a list of antidepressants medications
http://www.fda.gov/Drugs/DrugSafety/InformationbyDrugClass/UCM096273
The following website lists a list of antidepressants medications
http://www.fda.gov/Drugs/DrugSafety/InformationbyDrugClass/UCM096273
Neurotransmitter Depletion Drugs
Drugs used to treat ADHD and depressions are reuptake inhibitors which block neurotransmitters from reaching the brain which in turn causes neurotransmitter depletion. When neurotransmitter depletion gets low enough it causes people to act irrationally and commit suicide. The FDA requires all neurotransmitter depletion drugs have a black box warning on them that most people pay little attention to. These drugs are among the few drugs classes that side effects can actually worsen the illness while trying to treat it. These drugs should be carefully monitored by physicians by watching the patient’s diet, giving proper nutrient supplements, and following up with neurotransmitter testing.
(Marty L. Hinz, MD.,http://www.neuroassist.com/,10/10/2009)
For more information on this topic go to www.neuroassist.com
This is a video that explains and draws a picture of what is happening in the body.
(Marty L. Hinz, MD.,http://www.neuroassist.com/,10/10/2009)
For more information on this topic go to www.neuroassist.com
This is a video that explains and draws a picture of what is happening in the body.
Prescription Pills: The Teenage Drug of Choice
Prescriptions drugs have evolved extravagantly, sales have grown more than four times since the 90's. This class of drugs have become the most-accelerated to be abused, they are the most commonly used between the ages of 12-24. For example, Ryan Smith was a junior in high school, when he was given his first vicodin. The sensation he felt was incredible, and over the next year he moved on to other pills such as, Xanax, Valium, OxyContin and Adderall. His brother began using them the same way he did, and eventually he went into an addiction program. They were some of the lucky ones.
The advertisements shown on television appear to the viewing audience as being able to achieve a higher degree of euphoria and level of achievement in their lives.
According to a survey from the University of Michigan, 14% of high school students from around the world have taken prescription drugs for non-medical reasons at some point in their lifetime. They mirror the exact same drugs that adults prefer.
Prescription drugs have become a nationwide problem. More and more adults and children are relying on them to correct their conditions such as, anxiety, depression and pain. Since these prescribed drugs are more readily available, our high school students are experimenting more frequently. They find them more appealing, since they are prescribed by a doctor and ultimately leading them into drug abuse and addiction.
(Daniel Costello., http://www.prescriptionsuicide.com, October 10, 2009)
The advertisements shown on television appear to the viewing audience as being able to achieve a higher degree of euphoria and level of achievement in their lives.
According to a survey from the University of Michigan, 14% of high school students from around the world have taken prescription drugs for non-medical reasons at some point in their lifetime. They mirror the exact same drugs that adults prefer.
Prescription drugs have become a nationwide problem. More and more adults and children are relying on them to correct their conditions such as, anxiety, depression and pain. Since these prescribed drugs are more readily available, our high school students are experimenting more frequently. They find them more appealing, since they are prescribed by a doctor and ultimately leading them into drug abuse and addiction.
(Daniel Costello., http://www.prescriptionsuicide.com, October 10, 2009)
Nutritional Therapies for Mental Disorders
We have become co-dependent on pharmacotherapy. When we go to the doctor because we are not feeling well we expect the doctor to prescribe us a medication to make us feel better, but there are alternatives that we can use to improve our health. For example our nutrition.
According to the Diagnostic and Statistical Manual of Mental Disorders, 4 out of the 10 leading causes of disability in the US and other develop countries are mental disorders; major depression, bipolar disorder, schizophrenia, and obsessive compulsive disorder. Studies show that a lack of certain dietary nutrients contribute to the development of mental disorders. The deficient nutrients are in vitmanins, minerals and omega-3 fatty acids. Instead of providing a drug, daily supplements can be used to reduce symptoms. For example, supplements that contain amino acids help reduce symptoms because they are converted to neurotransmitters that alleviate depression and other mental disorders. The supplements do not have the side effects medications have.
For patients who suffer from major depression it is recommended to take dietary supplements that contain tyrosine and or phenylalanine because lead to alertness and arousal. Increase the intake of omega-3 fatty acids by eating more fish can stimulate mood elevation in depressed patients.
(Shaheen E Lakhan and Karen F Vieira, 2008, Bio Med Central, http://www.nutritionj.com/content/7/1/2)
According to the Diagnostic and Statistical Manual of Mental Disorders, 4 out of the 10 leading causes of disability in the US and other develop countries are mental disorders; major depression, bipolar disorder, schizophrenia, and obsessive compulsive disorder. Studies show that a lack of certain dietary nutrients contribute to the development of mental disorders. The deficient nutrients are in vitmanins, minerals and omega-3 fatty acids. Instead of providing a drug, daily supplements can be used to reduce symptoms. For example, supplements that contain amino acids help reduce symptoms because they are converted to neurotransmitters that alleviate depression and other mental disorders. The supplements do not have the side effects medications have.
For patients who suffer from major depression it is recommended to take dietary supplements that contain tyrosine and or phenylalanine because lead to alertness and arousal. Increase the intake of omega-3 fatty acids by eating more fish can stimulate mood elevation in depressed patients.
(Shaheen E Lakhan and Karen F Vieira, 2008, Bio Med Central, http://www.nutritionj.com/content/7/1/2)
Writing a Wrong: Factors Influencing the Overprescription of Antidepressants to Youth
Depression is not a necessary precondition for suicide, but it is clear that depressed patients are at higher risk for this behavior. So does depression and suicide correlate. According to Rudd, Corderom and Bryan, causality is not demonstrated between a reduction in antidepressants use and an observed increase in suicide rates. In order to argue the case of a direct relationship between antidepressants prescriptions and suicide, three factors must be considered.
1. an association between use of antidepressants and a decline in suicide rates
2. an association between the use of antidepressants and an increas in suicide rates
3. the overall incidence of suicide in a given population
After the introduction of antidrepressants such as fluoxetine and other serotonin reuptake inhibitors (SRIs) a decline in overall suicide rates has been observed,but direct casuality cannot be imputed.
The Centers for Disease Control and Prevention data for suicide is, age adjusted suicide rates per 100,000 (for all ages) were 12.5 in 1990 and 10.9 in 2005. Declines for adolescents ages 15-24 years also dropped from 12.3/100,000 in 1980 to below 12/100,000 in 1996 and then in 2003, 9.7/100,000.
Other factors could have influenced in the decline of suicides such as, the presence or absence of suicide education and prevention programs, the availability of mental health services, and better data collection mechanisms for reporting suicides.
A very important factor that arose in 2004 was the black box warning which resulted from an increase in reported suicidal behavior among children and adolescents taking antidepressants.
(Morgan T Sammons, 2009,Professional Psychology: Research and Practice 2009, Vol 40 rptd in American Psychological Association)
1. an association between use of antidepressants and a decline in suicide rates
2. an association between the use of antidepressants and an increas in suicide rates
3. the overall incidence of suicide in a given population
After the introduction of antidrepressants such as fluoxetine and other serotonin reuptake inhibitors (SRIs) a decline in overall suicide rates has been observed,but direct casuality cannot be imputed.
The Centers for Disease Control and Prevention data for suicide is, age adjusted suicide rates per 100,000 (for all ages) were 12.5 in 1990 and 10.9 in 2005. Declines for adolescents ages 15-24 years also dropped from 12.3/100,000 in 1980 to below 12/100,000 in 1996 and then in 2003, 9.7/100,000.
Other factors could have influenced in the decline of suicides such as, the presence or absence of suicide education and prevention programs, the availability of mental health services, and better data collection mechanisms for reporting suicides.
A very important factor that arose in 2004 was the black box warning which resulted from an increase in reported suicidal behavior among children and adolescents taking antidepressants.
(Morgan T Sammons, 2009,Professional Psychology: Research and Practice 2009, Vol 40 rptd in American Psychological Association)
The Use of Overdose Slow Release Clomipramine
Suicide by overdosing on their own medications is a common risk in patients with psychiatric disorders. This is a reason why less toxic antidepressants should be prescribed to individuals with a history of suicide attempts. The following is case report were an individual abused the drug Clomipramine. Clomipramine is a selective serotonin reuptake inhibitor (SSRI) but it is also a tricyclic compound that has been used for the pharmacological treatment of obsessive-compulsive disorder (OCD) and has been replaced by other safer selective serotonin reuptake inhibitors.
A 41-year-old female was admitted to the emergency room after taking 20 pills of 75mg clomipramine slow release tablets.She had a history of OCD for the last 11 years. When admitted to the hospital, the initial physical examination revealed vomiting and palpilation only. Vital signs were 140/85 mmHg, and 107 heart rate per minute. ECG showed sinus tachycardia and she experienced tonic-clonic seizures two hours after admission. She became fully oriented on day 2.
Therfore it is suggested that the use of tricyclic antidepressants (TCA) should be avoided in patients with suicidal tendency.
(Muhammet Gozdemir, Mehmet Erkan Ozcan, 2009,Bulletin of Clinical Psychopharmacology,Vol:19,www.psikofarmakoloji.org )
A 41-year-old female was admitted to the emergency room after taking 20 pills of 75mg clomipramine slow release tablets.She had a history of OCD for the last 11 years. When admitted to the hospital, the initial physical examination revealed vomiting and palpilation only. Vital signs were 140/85 mmHg, and 107 heart rate per minute. ECG showed sinus tachycardia and she experienced tonic-clonic seizures two hours after admission. She became fully oriented on day 2.
Therfore it is suggested that the use of tricyclic antidepressants (TCA) should be avoided in patients with suicidal tendency.
(Muhammet Gozdemir, Mehmet Erkan Ozcan, 2009,Bulletin of Clinical Psychopharmacology,Vol:19,www.psikofarmakoloji.org )
Can Antidepressants cause Suicide instead of Preventing it?
Drugs taken as antidepressants such as Prozac, Luvox and Paxil are selective serotonin reuptake inhibitors, more commonly known as SSRI's. One of the brain's most important biochemicals is serotonin, controlling a person's appetite to their mood swings. Some good clues to look for if a person is lacking seratonin are depression, compulsive eating or gambling, moodiness or not sleeping properly. However, too much of a good thing is bad, and can raise seratonin levels too high and can make the brain react in ways similar to mental illness.(Dani Veracity, www.naturalhealth.com, 10/10/2009)
Prescription Drug and Suicide Connection
The Food and Drug Administration are now focusing on the risk of suicide in adolescents while taking antidepressants. One of the major risk factors associated with physical illness is depression. We can easily confuse our everyday emotional struggles with the mental health side effects. Here we have two examples of distinctly prescribed medications who experienced suicide in their family firsthand.
Cody Miller, a high school football player, was taking a prescribed drug for his allergies, but switched to Singulair because the doctor assured his mother to be better. He began showing signs of being anxious and moody. Approximately two weeks after starting his newly prescibed medication, he was found hung in a closet in the family's home.
Douglas Briggs, a physician, was taking medication because of an old back injury starting in February of 2004. He was prescribed Neurontin, an epileptic drug that would help in the treatment of his nerve-related, chronic back pain. Soon after he began taking this medication his family noticed some abnormal behaviors. He expressed to his family a losing desire for practicing medicine, which was completely startling to the family since he had such a great passion for it. On Christmas Day 2004, he convinced his family to go watch a movie. When the family returned home, he was found hung in the their foyer.
Though some medications are identified to specifically treat certain problems, there is a possibility of getting into the brain, which is potential for psychiatric side effects. Not all medications do, and because our brain is protected by a cellular barrier, they block many new substances from circulating in our blood. A very important question scientists have to ask, is if the drug will affect the brain, especially with mental health side effects.
(Associated Press., http:www.foxnews.com, October 10, 2009)
Cody Miller, a high school football player, was taking a prescribed drug for his allergies, but switched to Singulair because the doctor assured his mother to be better. He began showing signs of being anxious and moody. Approximately two weeks after starting his newly prescibed medication, he was found hung in a closet in the family's home.
Douglas Briggs, a physician, was taking medication because of an old back injury starting in February of 2004. He was prescribed Neurontin, an epileptic drug that would help in the treatment of his nerve-related, chronic back pain. Soon after he began taking this medication his family noticed some abnormal behaviors. He expressed to his family a losing desire for practicing medicine, which was completely startling to the family since he had such a great passion for it. On Christmas Day 2004, he convinced his family to go watch a movie. When the family returned home, he was found hung in the their foyer.
Though some medications are identified to specifically treat certain problems, there is a possibility of getting into the brain, which is potential for psychiatric side effects. Not all medications do, and because our brain is protected by a cellular barrier, they block many new substances from circulating in our blood. A very important question scientists have to ask, is if the drug will affect the brain, especially with mental health side effects.
(Associated Press., http:www.foxnews.com, October 10, 2009)
This subject is a very controversal issue for everyone many people take these drugs and have not such side effects and then there are the unfortunate few who take them and have horrific side effect like suicide. But usually the patients that take these ssri drugs are already suffering from depression and might already have suicidal thoughts. People say well the medication didnt put the gun up to the persons head they decided to do that themselves with their own two hands. Others might say if they werent on the medication in the first place the gun might never have benn in their hand to begin with. So as you can see there are many different views of this situation. But as healthcare workers and family members of people taking these drugs we need to be very aware of the potential problems they might face, and be observant of sudden mood or personality changes as well as informing the patient of the side effects.
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